Urinary Metalloproteinases: Noninvasive Biomarkers for Breast Cancer Risk Assessment
作者： Susan E. Pories , David Zurakowski , Roopali Roy , Carolyn C. Lamb , Sughra Raza
DOI: 10.1158/1055-9965.EPI-07-0365
关键词:
摘要: Matrix metalloproteinases (MMP) and a disintegrin metalloprotease 12 (ADAM 12) can be detected in the urine of breast cancer patients provide independent prediction disease status. To evaluate potential urinary as biomarkers to predict risk status, samples from women with known marker lesions, atypical hyperplasia lobular carcinoma situ (LCIS), were analyzed. Urine obtained 148 women: 44 hyperplasia, 24 LCIS, 80 healthy controls. MMP analysis was done using gelatin zymography ADAM via immunoblotting monospecific antibodies subsequent densitometric measurement. Positive MMP-9 levels indicated 5-fold >13-fold LCIS compared normal Urinary significantly elevated controls, receiver operating characteristic curve showing an area under 0.914 0.950, respectively. assess clinical applicability, predictive index developed conjunction Gail scores for atypia. Scores above 2.8 on this 12-Gail score are (sensitivity, 0.976; specificity, 0.977). Our data suggest that noninvasive detection important information use identification at increased developing cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(5):1034–12)
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