Hippocampal kindling leads to motor map expansion.

摘要: Summary: Purpose: To determine whether seizure activity, repeatedly elicited in the hippocampus, could alter functional organization of neocortical movement representations (motor maps) and a relation exists between number afterdischarges recorded sensorimotor neocortex size motor maps. Methods: We electrically kindled right ventral hippocampus Long‐Evans hooded rats, twice daily, for 40 sessions stimulated neocortex. Between 3 7 days after last seizure, we used high-resolution intracortical microstimulation to derive forelimb-movement left (un-implanted) Results: In hippocampal observed dramatic expansion area that would elicit forelimb movements compared with sham-kindled controls. The was significantly positively correlated Conclusions: Seizures propagating from have long-distance effects on Key Words: Motor cortex— Movement representations—Hippocampus—Afterdischarge— Seizure—Epilepsy.