Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments

摘要: Antimicrobial resistance (AMR) represents a major global health threat, as well hazard to sustainable economic development and national security. It remains, therefore, vital that current research aligns policy implementation alleviate potential crisis. One must consider, for example, whether drivers of antibiotic can be controlled in the future, or have they already accumulated past, from antibiotics and/or other pollutants? Unfortunately, industrial heritage its pollution impact on prevalence environmental AMR largely been ignored. Focussing industrialised estuaries, we demonstrate anthropogenic inputs addition natural diurnal conditions sufficiently create stressful microbiome thus promote selective pressures shift resistome (i.e., collection traits microbiological community). bacteria’s survival mechanisms, via co-selective pressures, affect their susceptibility antibiotics. This review highlights complexity estuarine environments, using two key contaminant groups (metals/toxic elements polyaromatic hydrocarbons), through which variety possible chemical biological pollutant stressors emergence dissemination antimicrobial resistance. We find compelling divers call more focused historically disrupted ecosystems, propagating real world.