Dramatic clinical and radiographic response to BRAF inhibition in a patient with progressive disseminated optic pathway glioma refractory to MEK inhibition.
作者： Abhishek Bavle , Jeremy Jones , Frank Y. Lin , Amy Malphrus , Adekunle Adesina
DOI: 10.1080/08880018.2017.1360971
关键词:
摘要: While clinical and radiographic responses to agents targeting the mitogen-activated protein kinases (MAPK) pathway have been repor-ted in pediatric low-grade gliomas (LGG), early phase trials indicate refractoriness these medications some of patients. We report a patient with disseminated LGG BRAFV600E mutation, which was refractory selumetinib, MEK inhibitor, but subsequently showed immediate response dabrafenib, BRAF sustained effect for 9 months prior progression. In LGGs, treatment resistance one agent MAPK might not imply other this pathway.
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