Elevated serum complement C3 levels are related to the development of prediabetes in an adult population: the Tianjin Chronic Low-Grade Systematic Inflammation and Health Cohort Study

摘要: Aims To investigate whether serum complement C3 is related to the prevalence and incidence of prediabetes in an adult population. Methods A cross-sectional (n = 10 206) prospective cohort study (n = 3333), with a mean (range; 95% CI) follow-up 2.63 (1–6; 2.58–2.68) years, was conducted people recruited from Health Management Centre Tianjin Medical University General Hospital Tianjin, China. Measurement concentration, blood fasting glucose, oral glucose tolerance, HbA1c other potential confounding factors performed at baseline each year during follow-up. Prediabetes defined according criteria American Diabetes Association. Adjusted logistic and Cox proportional hazards regression models were used assess relationships between quintiles prediabetes. Results The 38.5% 119 per 1000 person-years, respectively. In analysis, after adjustment for confounders, odds ratios increasing of C3 1.00 (reference), 1.32 (95% CI 1.14–1.53), 1.37 1.18–1.59), 1.75 1.51–2.03), 2.25 1.93–2.62; P trend < 0.0001). multiple-adjusted hazard ratio highest quintile 1.43 1.15, 1.78; trend < 0.001), when compared lowest quintile. Conclusions These findings indicate that elevated levels are significantly increased risk developing population, suggesting can be as biomarker high-risk individuals improve primary prevention diabetes.