Les autres inhibiteurs tyrosine kinase de KIT ou de la voie AKT
作者： I. Ray-Coquard , T. Bachelot , J. -P. Guastalla , J. -Y. Blay
DOI: 10.1007/978-2-287-36008-4_8
关键词:
摘要: Les tumeurs stromales gastro-intestinales sont des rares, pouvant se localiser a tous les etages du tractus digestif, et representant 10 50% sarcomes tissus mous. Elles representent une entite nosologique particuliere depuis la decouverte de leur lien avec cellules Cajal, pacemakers motricite digestive. Sur le plan phenotypique, tumorales GIST caracterisees par ľexpression marqueur CD34, commun aux recepteur tyrosine kinase c-kit (CD117) sous forme mutee et/ou activee (1). desormais en 1998 surface (2). Ces mutations survenue precoce il est possible qu’elles constituent meme ľevenement oncogenetique initial maladie. Avant ľimatinib, chirurgie etait seul traitement efficace cette pathologie, chimiotherapie restant globalement inoperante, radiotherapie non applicable.
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