Respiratory Diseases and Helicobacter pylori Infection: Is There a Link?

摘要: Recent studies suggest an epidemiological association between Helicobacter pylori infection and several extra-gastroduodenal pathologies, including cardiovascular, rheumatic, skin liver diseases. The observed associations might be explained by a role of H. in the pathogenesis certain extra-digestive disorders, as variety inflammatory mediators are activated infection. present review summarizes current literature, our own studies, concerning respiratory diseases A small number serologic case-control that patients with chronic obstructive pulmonary disease have increased seroprevalence pylori. frequent coexistence bronchiectasis has also been found. Moreover, recent shown prevalence tuberculosis those lung cancer. On other hand, bronchial asthma does not seem to related At present, there is no definite proof causal relationship primary evidence rests on relatively numbers patients. Future should large enough for moderate-sized effects assessed or registered reliably. activation pathogenetic mechanism underlying associations. Therefore, genetic predisposition infected host, presence strain-specific virulence factors serum concentration proinflammatory markers pylori-infected need further evaluation.