Caffeic acid and cinnamic acid ameliorate glucose metabolism via modulating glycogenesis and gluconeogenesis in insulin-resistant mouse hepatocytes
作者： Da-Wei Huang , Szu-Chuan Shen
DOI: 10.1016/J.JFF.2012.01.005
关键词:
摘要: Abstract Tumour necrosis factor-α (TNF-α) plays a pivotal role in cellular insulin resistance and can induce mouse FL83B hepatocytes. Caffeic acid cinnamic were found to improve glucose uptake TNF-α-treated insulin-resistant The mechanism of metabolism by caffeic was further investigated. result from Western blot analysis revealed that increased expression glycogen synthase, whereas the synthase kinase phosphorylation at Ser641 hepatocytes decreased. suppressed hepatic nuclear factor-4 activity phosphoenolpyruvate carboxykinase also inhibited. Thus, ameliorated promoting glycogenesis inhibiting gluconeogenesis
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Claudine Manach, Augustin Scalbert, Christine Morand, Christian Rémésy, Liliana Jiménez, Polyphenols: food sources and bioavailability The American Journal of Clinical Nutrition. ,vol. 79, pp. 727- 747 ,(2004) , 10.1093/AJCN/79.5.727
Carlos Viijlar‐Palasí, Joan J. Guinovart, The role of glucose 6-phosphate in the control of glycogen synthase. The FASEB Journal. ,vol. 11, pp. 544- 558 ,(1997) , 10.1096/FASEBJ.11.7.9212078
M. Niehof, J. Borlak, HNF4α and the Ca-Channel TRPC1 Are Novel Disease Candidate Genes in Diabetic Nephropathy Diabetes. ,vol. 57, pp. 1069- 1077 ,(2008) , 10.2337/DB07-1065
Isabelle A. Leclercq, Alain Da Silva Morais, Ben Schroyen, Noémi Van Hul, Albert Geerts, Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences Journal of Hepatology. ,vol. 47, pp. 142- 156 ,(2007) , 10.1016/J.JHEP.2007.04.002
Pascal Peraldi, Gökhan S. Hotamisligil, Wim A. Buurman, Morris F. White, Bruce M. Spiegelman, Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase Journal of Biological Chemistry. ,vol. 271, pp. 13018- 13022 ,(1996) , 10.1074/JBC.271.22.13018
T. Ferre, A. Pujol, E. Riu, F. Bosch, A. Valera, Correction of diabetic alterations by glucokinase Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 7225- 7230 ,(1996) , 10.1073/PNAS.93.14.7225
Claudia González-Espinosa, Marı́a Teresa Romero-Ávila, Dulce Marı́a Mora-Rodrı́guez, Diana González-Espinosa, J.Adolfo Garcı́a-Sáinz, Molecular cloning and functional expression of the guinea pig α1a-adrenoceptor European Journal of Pharmacology. ,vol. 426, pp. 147- 155 ,(2001) , 10.1016/S0014-2999(01)01217-1
Juei-Tang Cheng, I-Min Liu, Stimulatory effect of caffeic acid on α 1A -adrenoceptors to increase glucose uptake into cultured C 2 C 12 cells Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 362, pp. 122- 127 ,(2000) , 10.1007/S002100000274
Da-Wei Huang, Szu-Chuan Shen, James Swi-Bea Wu, Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 7687- 7692 ,(2009) , 10.1021/JF901376X
Catherine Postic, Masakazu Shiota, Kevin D. Niswender, Thomas L. Jetton, Yeujin Chen, J. Michael Moates, Kathy D. Shelton, Jill Lindner, Alan D. Cherrington, Mark A. Magnuson, Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. Journal of Biological Chemistry. ,vol. 274, pp. 305- 315 ,(1999) , 10.1074/JBC.274.1.305