Effect of transplantable plasma-cell tumors on antibody response in mice.

摘要: The response to primary antigenic stimulation was measured in C3H mice bearing two types of plasma-cell tumours, the 5563 tumour producing γ-type myeloma proteins and 5674 β-type proteins. Haemocyanin pneumococcus type III polysaccharide, which produce 6.5S antibodies, sheep erythrocytes, 18S haemolysins, were used. Levels serum antibody all antigens low with compared those normal mice, or a mammary carcinoma. larger tumour, lower levels. Antibody levels generally tumours than 5647 similar weight. Although rapid catabolism gamma globulins contributes level diminished responsiveness antigen-susceptible cells appears be principal factor impaired tumour.