Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task.

摘要: Abstract In this study, we characterized more thoroughly the social behavior of vasopressin 1b receptor null (V1bR−/−) mice. We confirmed that V1bR−/− males exhibit less aggression than their wild-type (V1bR+/+) littermates. tested preference by giving male subjects a choice between pairs soiled or clean bedding. general, V1bR+/+ mice spent significantly time engaged in chemoinvestigation these stimuli Male preferred female-soiled bedding over male-soiled bedding, and contrast, failed to for any This difference is not explained an anosmic condition as there were no differences abilities detect cookie buried ability perform operant conditioning task using fully automated liquid dilution olfactometer. latter task, capable discriminating female mouse urine. The latencies learn did differ two genotypes. Thus, male's differentiate chemosensory cues appears different male's. propose V1bR plays important role motivation, perhaps coupling processing, integration, and/or interpretation with appropriate behavioral response.