Possible Mechanism Responsible for the Acquisition of Resistance to Cis-Diamminedichloroplatinum (II) by Cultured Human Testicular Seminoma Cells
作者： TATSUYA KOBAYASHI , TOMOHIRO FUJII , YOSHIMASA JO , KEIGO KINUGAWA , MASATO FUJISAWA
DOI: 10.1097/01.JU.0000122901.70300.20
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摘要: ABSTRACTPurpose: We established a cis-diamminedichloroplatinum (II) (CDDP) resistant cell line and determined the mechanisms of CDDP resistance.Materials Methods: The JKT/DDP was from highly metastatic human testicular seminoma JKT-HM by long-term intermittent administration low dose CDDP. Growth curves, sensitivity intracellular concentrations were compared in JKT/DDP, JKT-1 cells. Expression mRNA MDR1, MRP, LRP GST-π also compared.Results: growth curve doubling time similar to those culture without but different with added culture. Morphologically cytoplasm segmentation chromatin aggregation observed when present, while cells spindle-shaped showed cobblestone growth.The IC50 for collagen gel drop embedded drug test that JKT...
jurology.com 参考文章(22)
Kenneth D. Tew, Glutathione-Associated Enzymes In Anticancer Drug Resistance. Cancer Research. ,vol. 76, pp. 7- 9 ,(2016) , 10.1158/0008-5472.CAN-15-3143
K Nakagawa, N Saijo, S Tsuchida, M Sakai, Y Tsunokawa, J Yokota, M Muramatsu, K Sato, M Terada, K D Tew, Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines. Journal of Biological Chemistry. ,vol. 265, pp. 4296- 4301 ,(1990) , 10.1016/S0021-9258(19)39562-6
Jo, Kinugawa, Matsuki, Morioka, Tanaka, Analysis of the biological properties and use of comparative genomic hybridization to locate chromosomal aberrations in the human testicular seminoma cell line JKT-1 and its highly metastatic cell line JKT-HM. BJUI. ,vol. 83, pp. 469- 475 ,(2001) , 10.1046/J.1464-410X.1999.00928.X
Kazuhiro Kagotani, Shin-ichi Akiyama, Morimasa Wada, Michihiko Kuwano, Ken Taniguchi, Takeshi Kawabe, Kimitoshi Kohno, Mina Kawakami, Katsuzumi Okumura, Takanori Nakamura, A Human Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene Is Overexpressed in Cisplatin-resistant Human Cancer Cell Lines with Decreased Drug Accumulation Cancer Research. ,vol. 56, pp. 4124- 4129 ,(1996)
Wj Sluiter, Gj Meersma, H Timmerbosscha, Ege Devries, C Meijer, Nh Mulder, Relationship of Cellular Glutathione to the Cytotoxicity and Resistance of Seven Platinum Compounds Cancer Research. ,vol. 52, pp. 6885- 6889 ,(1992)
David J. Waxman, Pramod K. Srivastava, David P. Lapenson, Scott S. Sundseth, Gene-specific Oligonucleotide Probes for α, µ, π, and Microsomal Rat Glutathione S-transferases: Analysis of Liver Transferase Expression and Its Modulation by Hepatic Enzyme Inducers and Platinum Anticancer Drugs Cancer Research. ,vol. 52, pp. 5797- 5802 ,(1992)
M F Pera, H C Harder, Analysis for platinum in biological material by flameless atomic absorption spectrometry. Clinical Chemistry. ,vol. 23, pp. 1245- 1249 ,(1977) , 10.1093/CLINCHEM/23.7.1245
C. Cillo, V. Ling, R. P. Hill, Drug resistance in kht fibrosarcoma cell lines with different metastatic ability International Journal of Cancer. ,vol. 43, pp. 107- 111 ,(1989) , 10.1002/IJC.2910430121
Tohru Mizushima, Yuichi Ishikawa, Eishi Obana, Masakazu Hase, Toshio Kubota, Tsutomu Katayama, Toyoki Kunitake, Eiji Watanabe, Kazuhisa Sekimizu, Influence of Cluster Formation of Acidic Phospholipids on Decrease in the Affinity for ATP of DnaA Protein Journal of Biological Chemistry. ,vol. 271, pp. 3633- 3638 ,(1996) , 10.1074/JBC.271.7.3633
P Mistry, LR Kelland, G Abel, S Sidhar, KR Harrap, The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines British Journal of Cancer. ,vol. 64, pp. 215- 220 ,(1991) , 10.1038/BJC.1991.279