An association study of sodium-lithium countertransport activity with glutathione S transferase (GST) T1 and GST M1 null polymorphisms in Greek dyslipidaemic patients and controls.
作者： Antonis Goulas , Maria Kosmidou , Apostolos I. Hatzitolios , Nikos Raikos , Dimitra Molyva
关键词:
摘要: Background: Previous genomic linkage studies have produced evidence linking sodium-lithium countertransport activity (Na/Li CT) with various chromosomal regions including loci harbouring glutathione S transferase (GST) genes. The aim of this study was to examine the putative association erythrocyte Na/Li CT GST T1 and M1 gene null polymorphisms. Methods: determined in erythrocytes isolated from 85 individuals, using a standard assay procedure employing atomic absorption spectroscopy. Genotyping Ml polymorphisms accomplished multiplex PCR method. A general linear model age, sex, smoking, dyslipidaemia hypertension as covariates used genotypes. Results: Individuals genotype displayed marginally significantly (p=0.049) lower values compared those at least one copy gene. significance eliminated following adjustment for (p=0.150), but survived trend when sample limited normotensive normolipidaemic individuals (p=0.070). No detected between polymorphism activity. Conclusions: suggestive is line previously published data genetic biochemical analyses may be potential prognostic value regards behaviour development related pathologies under conditions oxidative insult.
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