A candidate gene approach of immune mediators effecting the susceptibility to and severity of upper gastrointestinal tract diseases in relation to Helicobacter pylori and Epstein-Barr virus infections.

摘要: This review focuses on immunogenetic aspects of diseases the upper gastrointestinal tract in which infectious agents may play a role aetiopathogenesis, such as Helicobacter pylori, Epstein-Barr virus (EBV) and HIV. Gastric adenocarcinoma is common cancer all around world, with declining incidences Europe high Asia central south America. Together gastric atrophy peptic ulcer disease, belongs to commonest diseases. These are multifactorial factors smoking dietary habits contribute pathogenesis. More recently, scientists have turned their eyes host. Functional polymorphisms genes regulating host immune system susceptibility progression disease. In polygenetic diseases, candidate gene studies single nucleotide (SNPs) detect small moderate relative risks. Unfortunately, only few functional SNPs been identified. The approach can be seen useful first step exploring causal pathways between genetic determinants complex those mentioned above. To date, little known about immunogenetics We literature H. EBV that affect key mediators influencing pathogenesis inflammatory response, code for IL-1 family, TNF-alpha, lymphotoxin alpha, IL-10. IL-1, IL-10, alpha TNF-alpha increase risk pylori-infected patients, whereas confer EBV-infected patients.