Acute effects of Hibiscus sabdariffa calyces on postprandial blood pressure, vascular function, blood lipids, biomarkers of insulin resistance and inflammation in humans

摘要: Background/Objectives: The acute impact of Hibiscus sabdariffa calyces (HSC) extract on postprandial vascular function and other cardiometabolic risk factors have not been studied previously. This study investigated the HSC consumption blood pressure (BP), markers. Subjects/Methods: Twenty-five men with 1% to 10% cardiovascular disease (CVD) (determined by QRISK®2) were randomised consume either 250 mL aqueous or water breakfast in a randomised, controlled, single-blinded, 2-meal cross-over (ClinicalTrials.gov, NTC02165553) two weeks washout period between days. BP was measured at baseline hourly for 4 h. Flow mediated dilatation (FMD) branchial artery baseline, 2 h post intervention drink consumption. Results: Acute caused significant increase % FMD (p < 0.001), non-significant decrease systolic (SBP) diastolic (DBP); urinary plasma nitric oxide (NOx) reduced response serum glucose, insulin, triacylglycerol C-reactive protein (CRP) levels; = 0.026) improvement area under systemic antioxidant curve (0 h); no changes arterial stiffness following HSC. Gallic acid, 4-O-methylgallic 3-O-methylgallic acid hippuric reached maximum concentration 1 Conclusion: improved may be useful dietary strategy reduce endothelial dysfunction CVD risk, although this requires confirmation.