Frozen Section and Imprint Cytology in Sentinel Lymph Node Biopsy for Breast Cancer

摘要: Recent trends toward conservative surgery for breast cancer and increasing detection of smaller invasive malignancies have shifted the traditional surgical approach from mastectomy to lumpectomy, complete axillary lymph node dissection sentinel biopsy avoid extensive procedures in clinically node-negative women (1),(2). Debate continues over radioisotope physical characteristics type dyes, as well optimal time injection role locoregional disease control ((1),(3). However, is successful 92% 98% patients increasingly being used staging prognostication, although low-volume micrometastatic may be present up 15% nonsentinel nodes when negative ((4),(5). Controversy also exists concerning extent tissue sampling modality pathological assessment most sensitive accurate metastatic ((1),(6). Although diagnostic armamentarium pathologist rapidly expanding due recent advances molecular techniques, laboratories intraoperative histology routinely done by either frozen section or imprint cytology, with rare selective use cytokeratin immunohistochemistry diagnostically equivocal cases ((7)–(10).