[Value of the determination of CA 15-3 in the diagnosis of malignant pleural effusion].

摘要: In 160 consecutive patients with pleural shedding, antigen CA 15-3 values in fluid were determined, a prospective way using monoclonal antibodies (115D8 and DF3). 49 malignant the mean value of (47.6 U/ml) was significantly higher (p less than 0.01) to 111 benign ones (12.9 U/ml). Its sensibility for malignity, trough level 27 U/ml, 37% an specificity 96%. When 100% required its (18%) lower carcinoembryonic (CEA) (33%), measured simultaneously comparative purposes. The simultaneous determination both markers raised 39%, without reaching statistical signification. ten whose sheddings secondary breast carcinoma, minimum (15 as medium (110 values, well (80%), found rest shedding origin, but clear superiority over obtained CEA. Based on these results, we conclude that usefulness determination, tumoral marker, fluid, is CEA seems not justified. We think specific secondaries carcinomas deserves study bigger sample.