Noninvasive biochemical markers of liver fibrosis.
作者： Mircea Grigorescu
DOI:
关键词:
摘要: The assessment of liver fibrosis provides useful information not only for diagnosis but also therapeutic decision. Although needle biopsy the is gold standard assessment, it has some technical limitations and risks. This led to development noninvasive biochemical markers fibrosis: direct which reflect extracellular matrix turnover indirect alterations in hepatic function. Markers associated with deposition or degradation cytokines implied may be used as individual combination generate an algorithm evaluate stage fibrosis. Also, predicted by using a single routine laboratory test multicomponent tests. Serum are great value patients at risk biopsy, part chronic disease avoiding invasive methods.
参考文章(84)
Kevin M. Walsh, Alexander Fletcher, Roderick N. M. MacSween, A. John Morris, Comparison of assays for N-amino terminal propeptide of type III procollagen in chronic hepatitis C by using receiver operating characteristic analysis. European Journal of Gastroenterology & Hepatology. ,vol. 11, pp. 827- 831 ,(1999) , 10.1097/00042737-199908000-00003
Klaus H.W. Boeker, Christian I. Haberkorn, Dirk Michels, Peer Flemming, Michael P. Manns, Ralf Lichtinghagen, Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C. Clinica Chimica Acta. ,vol. 316, pp. 71- 81 ,(2002) , 10.1016/S0009-8981(01)00730-6
Julia S Johansen, Per Christoffersen, Søren Møller, Paul A Price, Jens H Henriksen, Charly Garbarsch, Flemming Bendtsen, Serum YKL-40 is increased in patients with hepatic fibrosis Journal of Hepatology. ,vol. 32, pp. 911- 920 ,(2000) , 10.1016/S0168-8278(00)80095-1
K Breitkopf, Expression and matrix deposition of latent transforming growth factor β binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture Hepatology. ,vol. 33, pp. 387- 396 ,(2001) , 10.1053/JHEP.2001.21996
Pierre Pradat, Alfredo Alberti, Thierry Poynard, Juan-Ignacio Esteban, Ola Weiland, Patrick Marcellin, Salvatore Badalamenti, Christian Trépo, Predictive value of ALT levels for histologic findings in chronic hepatitis C: A European collaborative study Hepatology. ,vol. 36, pp. 973- 977 ,(2002) , 10.1053/JHEP.2002.35530
Toshikazu Nakamura, Yumiko Tomita, Reiko Hirai, Kazuko Yamaoka, Kazuhiko Kaji, Akira Ichihara, Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture Biochemical and Biophysical Research Communications. ,vol. 133, pp. 1042- 1050 ,(1985) , 10.1016/0006-291X(85)91241-0
Yoshikazu Murawaki, Yujiro Ikuta, Yuuko Nishimura, Masahiko Koda, Hironaka Kawasaki, Serum markers for connective tissue turnover in patients with chronic hepatitis B and chronic hepatitis C: a comparative analysis. Journal of Hepatology. ,vol. 23, pp. 145- 152 ,(1995) , 10.1016/0168-8278(95)80328-9
Thierry Poynard, Mona Munteanu, Françoise Imbert-Bismut, Frederic Charlotte, Dominique Thabut, Sophie Le Calvez, Djamila Messous, Vincent Thibault, Yves Benhamou, Joseph Moussalli, Vlad Ratziu, Prospective Analysis of Discordant Results between Biochemical Markers and Biopsy in Patients with Chronic Hepatitis C Clinical Chemistry. ,vol. 50, pp. 1344- 1355 ,(2004) , 10.1373/CLINCHEM.2004.032227
Manal Shahin, Detlef Schuppan, Rüdiger Waldherr, Juha Risteli, Leila Risteli, Eeva-Riitta Savolainen, Christine Oesterling, Hosna M. Abdel Rahman, Abdul M. El Sahly, Samia M. Abdel Razek, Omar El Ruby, Armin Koch, Helmut K. Seitz, Serum procollagen peptides and collagen type VI for the assessment of activity and degree of hepatic fibrosis in schistosomiasis and alcoholic liver disease Hepatology. ,vol. 15, pp. 637- 644 ,(1992) , 10.1002/HEP.1840150414
J P Iredale, G Murphy, R M Hembry, S L Friedman, M J Arthur, Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. Journal of Clinical Investigation. ,vol. 90, pp. 282- 287 ,(1992) , 10.1172/JCI115850