The detection of tyrosinase-specific mRNA in bone marrow is not more sensitive than in blood for the demonstration of micrometastatic melanoma.
作者： Waldmann , Deichmann , Bock , Jäckel , Näher
DOI: 10.1046/J.1365-2133.1999.02903.X
关键词:
摘要: Recent reports suggest that as a marker of progression malignant melanoma, the detection tyrosinase mRNA in blood is limited value. In present study, we investigated whether by reverse transcription-polymerase chain reaction (RT-PCR) bone marrow samples might be more useful method for micrometastatic melanoma. The presence was analysed and from 20 melanoma patients with widespread clinical metastases. Of these patients, 12 were negative both marrow. remaining eight had either or marrow: six blood, one but not sensitivity RT-PCR apparently does exceed metastatic patients. This seems to independent prior chemotherapy immunotherapy. contrast different solid tumours, significant reservoir tumour cells.
sci-hub.se 参考文章(15)
Julia A. Newton Bishop, Molecular pathology of melanoma Cancer and Metastasis Reviews. ,vol. 16, pp. 141- 154 ,(1997) , 10.1023/A:1005752510012
V. Waldmann, H.M. Rabes, What's new in ras genes? Physiological role of ras genes in signal transduction and significance of ras gene activation in tumorigenesis. Pathology Research and Practice. ,vol. 192, pp. 883- 891 ,(1996) , 10.1016/S0344-0338(96)80067-7
A. Hauschild, Die adjuvante und neoadjuvante Therapie des Melanoms Dermatologie. pp. 284- 287 ,(1998) , 10.1007/978-3-642-71974-5_72
A. Fourkour, D.J. Ruiter, Th. Wobbes, T.J. de Vries, G. Verkroost, G.N.P. van Muijen, Heterogeneous Expression of Immunotherapy Candidate Proteins gp100, MART-1, and Tyrosinase in Human Melanoma Cell Lines and in Human Melanocytic Lesions Cancer Research. ,vol. 57, pp. 3223- 3229 ,(1997)
Terry Sarantou, Andrew J. Conrad, Donald L. Morton, Dave S. B. Hoon, Dorcas D. J. Chi, Peter Schmid, Darryl A. Garrison, Melanoma-associated Antigens as Messenger RNA Detection Markers for Melanoma Cancer Research. ,vol. 57, pp. 1371- 1376 ,(1997)
D S Hoon, Y Wang, P S Dale, A J Conrad, P Schmid, D Garrison, C Kuo, L J Foshag, A J Nizze, D L Morton, Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay. Journal of Clinical Oncology. ,vol. 13, pp. 2109- 2116 ,(1995) , 10.1200/JCO.1995.13.8.2109
Anthony P. Albino, Christopher R. Shea, N. Scott McNutt, Oncogenes in melanomas. Journal of Dermatology. ,vol. 19, pp. 853- 867 ,(1992) , 10.1111/J.1346-8138.1992.TB03796.X
Uwe Reinhold, Hans-Christian Lüdtke-Handjery, Sylvia Schnautz, Hans-Wilhelm Kreysel, Hinrich Abken, The Analysis of Tyrosinase-Specific mRNA in Blood Samples of Melanoma Patients by RT-PCR Is Not a Useful Test for Metastic Tumor Progression Journal of Investigative Dermatology. ,vol. 108, pp. 166- 169 ,(1997) , 10.1111/1523-1747.EP12333341
Vernon K. Sondak, Julie A. Wolfe, Adjuvant therapy for melanoma. Current Opinion in Oncology. ,vol. 9, pp. 189- 204 ,(1997) , 10.1097/00001622-199703000-00015
F. Lindemann, J. Witte, G. Schlimok, P. Dirschedl, G. Riethmuller, Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients The Lancet. ,vol. 340, pp. 685- 689 ,(1992) , 10.1016/0140-6736(92)92230-D