Mast cell protease release and mucosal ultrastructure during intestinal anaphylaxis in the rat

摘要: Intestinal anaphylaxis is associated with disturbances in gut function that are antigen-specific and dependent on mast cell degranulation. Using an animal model of intestinal anaphylaxis, we have correlated alterations water electrolyte transport, intraluminal challenge, specific mucosal degranulation by following systemic as well local release rat protease II. This for cells known to selectively attack type IV collagen, which found basement membranes. Intraluminal antigen challenge sensitized animals dramatically increased serum levels Serum continued rise throughout the duration challenge. Although light microscopy challenged intestine demonstrated little distortion architecture, ultrastructural examination revealed significant disruption membrane underlying collagenous matrix mucosa. Our findings indicate during immunoglobulin E-mediated reactions, II released changes The appearance this provides a marker anaphylaxis.