High and low hemoglobin glycation phenotypes in type 1 diabetes A challenge for interpretation of glycemic control

摘要: This study tested the hypothesis that there are consistent individual differences in relationship between glycated hemoglobin (HbA1c) and mean blood glucose (MBG) levels individuals with similar preceding levels. Blood data were collected for up to 2.3 years by 128 children adolescents type 1 diabetes. HbA1c values date-matched MBG calculated from an average of 85 self-monitored measurements previous 30 days. There was significant linear correlation (HbA1c=0.027xMBG+5.8, n=682, r=.71, P<.0001) but also wide variability population response MBG. We a glycation index (HGI=observed HbA1c-predicted HbA1c) quantify magnitude direction difference each patient's set observed predicted results. Likelihood ratio tests t statistics showed HGI significantly different among individuals, 29% patients had statistically higher or lower than regression equation. The not related erythrocyte age no evidence analytical artifact. interpret these results as possible high low phenotypes within population. conclude necessarily interchangeable estimates glycemic control phenotype may be important clinical assessment diabetic patients.