Clinical Analysis of Structural Hemoglobin Variants and Hb A1c, by Capillary Isoelectric Focusing
作者： James M. Hempe , Alfonso Vargas , Randall D. Craver
DOI: 10.1007/978-1-59259-120-6_8
关键词: Diabetes management 、 Diabetes mellitus 、 Hemoglobin 、 Glycemic 、 Clinical pathology 、 Hemoglobin variants 、 Molecular biology 、 Beta thalassemia 、 Internal medicine 、 Medicine 、 Isoelectric focusing 、 Endocrinology
摘要: Capillary isoelectric focusing (cIEF) for analysis of hemoglobin (Hb) variants has two major clinical applications: 1) diagnosis and management congenital hemoglobinopathies, 2) assessment glycemic control in subjects with diabetes. For Hb disorders, like sickle-cell disease or beta thalassemia, the specific identification precise quantification both normal abnormal structural is required. Assessment diabetes management, on other hand, requires separation a post-translational variant, A1c, that chemically modified (glycated) form adult A.
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