Advanced glycation endproducts — associated parameters in the peripheral blood of patients with Alzheimer's disease

摘要: Advanced glycation endproducts (AGEs), structural components of beta-amyloid plaques and neurofibrillary tangels, have been implicated in the pathogenesis Alzheimer's disease. AGE levels, measured by fluorescence, their precursor molecules such as glucose its Amadori product, fructosylamine, were to examine question whether reported increased level AGEs brain is reflected an increase AGE-associated parameters peripheral blood. Lactoferrin, proposed play important role interaction with receptors, was determined ELISA. All showed trends lower values patients disease compared non-demented controls. Albumin total iron not significantly different between groups. In contrast diabetes renal failure, where high levels precursors are present tissue well blood, elevated CNS manifested without detectable changes.