Long-term fasting improves lipoprotein-associated atherogenic risk in humans.

摘要: Dyslipidemia is a major health concern associated with an increased risk of cardiovascular mortality. Long-term fasting (LF) has been shown to improve plasma lipid profile. We performed in-depth investigation lipoprotein composition. This observational study included 40 volunteers (50% men, aged 32–65 years), who underwent medically supervised fast 14 days (250 kcal/day). Changes in and levels, as well subclasses particles, were measured by ultracentrifugation nuclear magnetic resonance (NMR) at baseline, after 7 14 days. The largest changes found There significant reductions triglycerides (TG, − 0.35 ± 0.1 mmol/L), very low-density (VLDL)-TG (− 0.46 ± 0.08 mmol/L), VLDL-cholesterol (VLDL-C, − 0.16 ± 0.03 mmol/L) (LDL)-C (− 0.72 ± 0.14 mmol/L). Analysis LDL showed decrease LDL1-C (− 0.16 ± 0.05 mmol/L), LDL2-C (− 0.30 ± 0.06 mmol/L) LDL3-C (− 0.27 ± 0.05 mmol/L). NMR spectroscopy reduction large VLDL particles (− 5.18 ± 1.26 nmol/L), (− 244.13 ± 39.45 nmol/L) small (− 38.45 ± 44.04 nmol/L). A high-density (HDL)-C (− 0.16 ± 0.04 mmol/L) was observed. By contrast, the concentration HDL significantly raised. Apolipoprotein A1 decreased whereas apolipoprotein B, lipoprotein(a), fibrinogen high-sensitivity C-reactive protein unchanged. Our results suggest that LF improves levels ameliorates lipoprotein-associated atherogenic profile, suggesting linked dyslipidemia. Study registration number: DRKS-ID: DRKS00010111 Date registration: 03/06/2016 “retrospectively registered”.