Effects of meloxicam on renal function in dogs with hypotension during anaesthesia.

摘要: Abstract Objective To evaluate the effects of meloxicam on renal function in dogs anaesthetized and rendered hypotensive with acepromazine-thiopental-isoflurane. Animals Eight healthy beagles, four males females, 25.6 ± 19.3 months old weighing 12.8 2.0 kg. Materials methods Either suspension at a dose 0.133 mL kg −1 (0.2 mg ) or saline solution (control), were given by mouth (PO) randomized, cross-over fashion. The treatment control was 3 hours before anaesthesia. Dogs sedated intramuscular acepromazine 0.1 . Anaesthesia induced intravenous thiopental, followed tracheal intubation maintenance isoflurane oxygen air, delivered using semi-closed breathing system. Renal quantified serum biochemistry, urinalysis glomerular filtration rate measured scintigraphy. Analysis variance Friedman anova used for statistical analysis. Results Values (mean SD) mean arterial blood pressure did not differ significantly between treatments but low (54 7 mmHg) during Glomerular over time, results urine analysis within reference ranges after treatment. Conclusions Clinical relevance Meloxicam caused no adverse when to acepromazine, thiopental isoflurane.