Identical, unique p53 mutations in a primary ovarian mucinous adenocarcinoma and a synchronous contralateral ovarian mucinous tumor of low malignant potential suggest a common clonal origin.

摘要: The origin of malignant ovarian epithelial tumors is uncertain and has been the subject considerable controversy. Some favor theory in precursor lesions such as benign cystadenomas or low potential (LMP; borderline tumors), whereas others concept an independent carcinomas from surface epithelium inclusion cysts. Recently, demonstration identical molecular alterations morphologically areas within same tumor have suggested possibility that had undergone differentiation to a appearance. Because both were present tumor, however, progression component could not be excluded. We case simultaneous mucinous carcinoma contralateral LMP which exhibited identical, unique mutations p53 gene, suggesting clonal origin. these separate distinct tumors, we believe this provides strong support for hypothesis. also provide evidence markedly different levels expression with mutations.