Trends in antimicrobial resistance in Shigella species in Karachi, Pakistan.

摘要: Background: Shigellosis is a common cause of morbidity, especially in the very young and old, developing countries.  The disease treated with antibiotics. Surveillance antimicrobial resistance trends essential owing to global emergence resistance. Methodology: study involved 1,573 isolates Shigella species (1996-2007) that were analyzed for Results: majority specimens (1046; 66.5%) from pediatric population, these 887 (84.8%) under 5 years age (p = 0.001). S. flexineri was most frequent (54.5%) isolated. Isolation sonnei increased 15.4 % (1996) 39% (2007) Although none found sensitive all antibiotics tested, 58% (n =9 07) resistant ampicillin 85% 1,338) trimethoprim-sulfamethoxazole (TMP-SMX). Out total 198 (12.6%) nalidixic acid isolates, 6 (3.0%) also ofloxacin. Overall 1.7 ofloxacin, 2.4% ceftriaxone 2.3% combination ampicillin, TMP-SMX. Conclusion: Ofloxacin still an effective drug treatment acute shigellosis Pakistan. Emergence may have grave implications severe patients.