In silico aided thoughts on mitochondrial vitamin C transport.

摘要: The huge demand of mitochondria as the quantitatively most important sources ROS in majority heterotrophic cells for vitamin C is indisputable. reduced form vitamin, l-ascorbic acid, imported by an active mechanism requiring two sodium-dependent transporters (SVCT1 and SVCT2). oxidized form, dehydroascorbate taken up different members GLUT family. Because controversial experimental results picture on mitochondrial transport became quite obscure spring 2014. Thus silico prediction tools were applied aid support vitro vivo results. role GLUT1 a transporter could be reinforced predictions however presence GLUT10 not likely since this protein got far lowest localization scores. Furthermore possible roles GLUT9 11 can proposed leastwise base their computational analysis. In good concordance with newest observations SVCT2 also supported tools.