A study of the role of house dust mite in atopic dermatitis.

摘要: Subjects with positive skin-prick tests to house dust mite (HDM) solution, including those and without atopic dermatitis, participated in a double-blind, controlled study of the role HDM exposure pathogenesis dermatitis. solution diluent control were applied daily mildly eczematous or clinically uninvolved skin antecubital popliteal fossae, prior abrasion, for 5 days. Responses assessed by clinical grading system measurement area dermatitis; pruritus was recorded on visual analogue scales. The showed that marked moderate delayed local reactions developed one third patients dermatitis response application both skin. Relative sites, significant increases degree also sites. Application normal, unabraded prick test subjects history produced immediate urticarial responses which not seen at findings demonstrate antigen may be rapidly absorbed normal vehicle negative testing, no reactions. This provides objective evidence cutaneous