Radiosensitization of microorganisms by radical anions. II. Streptococcus faecalis.
作者： Jack Schubert , Henk Stegeman , Albert Groneman
DOI: 10.1080/09553008114551021
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摘要: SummaryThe inactivation of Streptococcus faecalis by radiolytically generated selective inorganic radical anions was investigated. The Br−2 radical, but not (CNS)−2, had a pronounced radiosensitizing action. In gamma-irradiated solutions at pH 7·0, the radiosensitization variety scavenging systems studied. Among these D10 for N2/Br− 0·082 kGy while N2O/CNS− = 0·35 kGy, N2O 0·25 N2 0·47, and O2 0·16 kGy. As shown previously, in N2O/Br− is due mainly to Br2 HOBr. From variation with (CNS)−2 it deduced that tyrosine crucial survival S. via enzymes essential residues such as aldolase lipoyl dehydrogenase which are presumably needed make energy available DNA repair. Studies scavengers also revealed t-butanol produced some damaging effect e−aq much less than OH sh...
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