The neisserial 37 kDa ferric binding protein (FbpA).

摘要: The ferric binding protein (FbpA) is one of the major proteins regulated by level environmental iron in genus Neisseria. Its conservation all species pathogenic Neisseria has been demonstrated, and possible role that it plays uptake mechanisms these bacteria postulated. Similar Haemophilus influenzae (HitA) Serratia marcescens (SfuA) have described, but relationships with meningococcal FbpA could not be proven. Although supposedly periplasmic, exact location remains controversial because some molecules, or parts them, found exposed to bacterial outer surface. DNA sequence downstream fbpA gene recently analysed, finding an operon composed three open reading frames: fbpA, encoding for FbpA; fbpB, codifies a cytoplasmic permease, fbpC, contains information nucleotide protein. These would form transport system through periplasmic space. highly antigenic mice when injected purified form, shows intraspecies interspecies homogenicity, specific anti-FbpA antibodies are fully cross-reactive; nevertheless, vivo induction man still polemical. Recent studies reveal induces fair response bactericidal mice.