Functional Connectivity and Brain Networks in Schizophrenia

摘要: Schizophrenia has often been conceived as a disorder of connectivity between components large-scale brain networks. We tested this hypothesis by measuring aspects both functional and network topology derived from resting-state fMRI time series acquired at 72 cerebral regions over 17 min 15 healthy volunteers (14 male, 1 female) 12 people diagnosed with schizophrenia (10 2 female). investigated between-group differences in strength diversity the 0.06-0.125 Hz frequency interval, some topological properties undirected graphs constructed thresholded interregional correlation matrices. In schizophrenia, was significantly decreased, whereas connections increased. Topologically, networks had reduced clustering small-worldness, probability high-degree hubs, increased robustness schizophrenic group. Reduced degree were locally significant medial parietal, premotor cingulate, right orbitofrontal cortical nodes schizophrenia. Functional metrics correlated each other behavioral performance on verbal fluency task. conclude that tend to have less strongly integrated, more diverse profile connectivity, associated hub-dominated configuration complex Alongside these behaviorally disadvantageous differences, however, group also showed greater random attack, pointing possible benefit connectome, if extremely expressed.