Survivin - an anti-apoptosis protein: its biological roles and implications for cancer and beyond.

摘要: Survivin is a protein that inhibits apoptosis and regulates cell division. contains baculovirus inhibitor of repeat (BIR) domain classifies it as member the (IAP) family. apoptosis, via its BIR domain, by either directly or indirectly interfering with function caspases. also chromosomal passenger required for expressed in embryonic tissues well majority human cancers, but not most normal adult tissues. The cancer-specific expression survivin, coupled importance inhibiting death regulating division, makes useful diagnostic marker cancer potential target treatment. Recently, there emerging evidence survivin involved tissue injury healing. Understanding mechanism can potentially allow development therapeutic strategies other diseases.