Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling

摘要: Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor apoptosis or IAP protein family involved in the control through a variety molecular mechanisms. The common aspect these proteins presence Baculovirus repeat domain, which protein–protein interactions with pro-survival pro-apoptotic proteins. Several also contain RING gives them ubiquitin E3 ligase activity plays major role antiapoptotic signaling. Given their importance signaling, elevated expression human malignancies, IAPs are an attractive therapeutic target.