GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney.
作者： Biying Liu , Haili Zhang , Xiao Tan , Daqian Yang , Zhanjun Lv
DOI: 10.18632/ONCOTARGET.15033
关键词:
摘要: // Biying Liu 1 , Haili Zhang Xiao Tan Daqian Yang Zhanjun Lv Huijie Jiang Jingjing Lu Ruiqi Baiyun and Zhigang College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China Correspondence to: Zhang, email: zhangzhigang@neau.edu.cn Keywords: grape seed procyanidin extract, kidney injury, oxidative stress, Nrf2, nephroprotective effect Received: September 24, 2016 Accepted: January 16, 2017 Published: February 02, 2017 ABSTRACT Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment Pb-induced nephrotoxicity remains elusive. Grape extract (GSPE) has beneficial properties for multiple biological functions. Therefore, present study investigated whether GSPE reduced as well protective mechanism in well-established 35-day Pb induced rat model. The results showed normalized histological damage, inflammatory, apoptosis, changes miR153 glycogen synthase kinase 3β (GSK-3β) levels kidney. Moreover, enhanced induction phase II detoxifying enzymes (heme oxygenase-1 NAD(P)H quinone oxidoreductase 1) by increasing nuclear factor-erythroid-2-related factor 2 (Nrf2) expression. This identifies first time stress attenuated via activating Nrf2 signaling pathway suppressing GSK-3β. provides new therapeutic target renal injury Pb, could be potential natural agent protect against
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