Protective effect of insulin and glucose at different concentrations on penicillin-induced astrocyte death on the primer astroglial cell line.

摘要: Astrocytes perform many functions in the brain and spinal cord. Glucose metabolism is important for astroglial cells astrocytes are only with insulin receptors brain. The common antibiotic penicillin also a chemical agent that causes degenerative effect on neuronal cell. aim of this study to show glucose at different concentrations astrocyte death induced by primer cell line. It well known intracranial treatment it used experimental epilepsy model commonly. Previous studies showed might protect case proper concentrations. But, present about against penicillin. For purpose, newborn rat was extracted then mechanically dissociated suspension finally grown culture medium. Clutters were maintained 2 weeks prior being these experiments. Different (0, 1, 3 nM) 3, 30 mM) media without 500 μM Penicillin decreased viability seriously. highest appeared medium nM mM but However, penicillin, best survival 1 glucose. We concluded protective effects damage Interestingly, depends strongly. results will help explain cerebrovascular pathologies parallel conditions patient after injuries.