Destruction of Rabbit Platelets in the Allergic Response of Sensitized Leukocytes I. Demonstration of a Fluid Phase Intermediate

摘要: The interaction of antigen with sensitized rabbit leukocytes results in histamine release and is cytotoxic for platelets the reaction mixtures. destruction requires no exogenous serum factors proportional to number Destruction follows one or more soluble intermediate(s) when react antigen. this factor(s) from Ca2+ (optimal at 3 × 10-4 M) inhibited by Mg2+. action factor on temperature sensitive essentially complete 5 min. activity required platelet also mediated not These observations suggest that associated extracellular appearance other, as yet unidentified substances whose both calcium dependent.