Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs

摘要: Transposable elements (TEs) comprise almost half of primate genomes and their aberrant regulation can result in deleterious effects. In pluripotent stem cells, rapidly evolving KRAB-ZNF genes target TEs for silencing by H3K9me3. To investigate the evolution TE silencing, we performed H3K9me3 ChIP-seq experiments induced cells from 10 human 7 chimpanzee individuals. We identified four million orthologous found SVA ERV families to be marked most frequently little evidence inter-species differences with as many 82% putatively silenced at similar levels humans chimpanzees. that are preferentially one species a age those both not more likely associated expression divergence nearby genes. Our data suggest limited species-specificity across 6 years evolution.