HIPEC Methodology, Comparison of Techniques, and Drug Regimens: Is There a Need for Standardization?

摘要: The introduction of cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has greatly improved the prognosis patients with peritoneal carcinomatosis in both phase II III trials. A clear pharmacologic clinical rationale for this treatment strategy been demonstrated. Whereas highly standardized, reproducible, predictable, same cannot be said modalities. staggering variety application techniques regimens reported. Most these have based on extrapolation systemic data. An urgent need more standardization modalities is needed. aim manuscript to review rationale, variables, chemotherapy. At time, it seeks offer guidance current potential directions toward standardization.