Theta responses are abnormal in mild cognitive impairment: evidence from analysis of theta event-related synchronization during a temporal expectancy task.

摘要: We examined the hypothesis that attention/executive deficits in mild cognitive impairment (MCI) due to Alzheimer’s disease is associated an abnormal cortical activation, revealed by method of event-related synchronization/desynchronization (ERS/ERD) theta band during a paradigm temporal orienting attention. MCI patients (n = 25) and healthy elderly (HE) matched controls (n = 15) performed task which periodically omitted tones had be predicted their virtual onset time marked pressing button. Single-trial responses were measured, respectively, before after motor response. Then, compared power eyes closed resting state (ERD/ERS method).The course was characterized two different behavioural conditions: (1) pre-event epoch, subject awaited tone, (2) post-event (after button pressing) post-motor response condition. The most important findings are summarized as follows: both groups, epoch ERS on electrodes, but HE greater group; condition, there prefrontal regions, and, also this case, showed enhancement patients; (3) evidence lateralization: waiting dominant right posterior lead (T6), whilst, left, well midline leads. Compared traditional neuropsychological measures for episodic memory, these indicators less accurate differentiating from elderly. clinical relevance weaker reactivity would indicate early attention stage neurodegenerative disease.