Taurine Release from Mouse Hippocampal Slices: Effects of Glutamatergic Substances and Hypoxia

摘要: The hippocampus is involved in many important functions, including generation of long-term potentiation, memory formation, learning, arousal, emotions and regulation autonomic functions. Since the major part excitatory innervation uses glutamate as transmitter (8), this region contains a high density receptors (26). activity network modulated by GABA, main inhibitory released local interneurons (11, 12). structural analogue taurine, found at concentrations (15, 21, 31), inhibits CA1 pyramidal neurons, increasing chloride conductance causing hyperpolarization (42). Taurine-like immunoreactivity has been localized interneurons, neurons dentate granule cells rat (5, 22). taurine-synthesizing enzyme cysteine sulfinate decarboxylase also identified basket Despite above findings no specific function assigned for taurine hippocampus.