Heritability of lumbar trabecular bone mechanical properties in baboons

摘要: Genetic effects on mechanical properties have been demonstrated in rodents, but not confirmed primates. Our aim was to quantify the proportion of variation vertebral trabecular bone that is due genes. L3 vertebrae were collected from 110 females and 46 male baboons (6-32 years old) a single extended pedigree. Cranio-caudally oriented cores scanned with microCT then tested monotonic compression determine apparent ultimate stress, modulus, toughness. Age sex heritability (h(2)) assessed using maximum likelihood-based variance components methods. Additive genes residual trait significant for stress (h(2)=0.58), toughness (h(2)=0.64), BV/TV (h(2)=0.55). When accounted for, by additive no longer significant. Toughness, however, showed evidence non-BV/TV-related genetic effect. Overall, modulus show strong are nearly entirely volume. Toughness shows related volume additional (accounting 10% total variance) independent These results support continued use as focal identify skeletal fragility, also other traits organic component matrix will enhance our ability find particularly relevant fatigue-related fractures.