8.15 Chromatographic Separations and Analysis: Diastereomeric Derivatization for Chromatography

摘要: Of the three branches of simultaneous determination enantiomers based on separation methods (indirect precolumn covalent, diastereomeric derivatization with homochiral derivatizing agents and achiral stationary phases, direct chiral phases or using additives in mobile phase), first is subject this chapter. Advantages disadvantages approach are discussed. It concluded that commercial availability a great variety several publications up to present time indicate cannot be considered outdated even era methods. The main for amines, amino acids, alcohols, carboxylic acids presented illustrated by examples published mainly last decade. Derivatization reagents aiming at enhancing possibilities also