Transport of fatty acids into adipocytes

摘要: The influx of diet-derived free fatty acids into adipose tissue leads to a variety metabolic and regulatory responses that affect both the development obesity homeostatic mechanisms linked adipocytokine synthesis secretion, as well insulin resistance inflammatory disease. Despite importance such in signal transduction, biochemical facilitate long-chain acid fat cells remain enigmatic. On basis and/or molecular genetic approaches, number adipocyte plasma membrane proteins have been implicated facilitating influx. This review focusses on description considered be major contributors influx, their identification evaluation gain or loss-of-function studies, potential modes action.