Effects of amiodarone therapy on thyroid function

摘要: Amiodarone is a benzofuran derivative approved for the treatment of cardiac arrhythmias. Traditionally classified as class III antiarrhythmic agent, amiodarone possesses electrophysiologic properties all four Vaughan-Williams classes. This drug, however, has high iodine content, and this feature plus intrinsic effects on body make especially toxic to thyroid gland. Treatment can result in range from mild derangements function overt hypothyroidism or thyrotoxicosis. The diagnosis amiodarone-induced usually straightforward, whereas that thyrotoxicosis ability distinguish between type 1 2 forms disease are much more challenging. Dronedarone was 2009 patients with atrial fibrillation. As amiodarone, dronedarone similar properties. In contrast structurally devoid notably shorter half-life. studies reported before FDA approval, proved be associated significantly fewer adverse than making it attractive choice fibrillation flutter, who at risk developing dysfunction.