Adenosine, lidocaine, and Mg2+ (ALM™) increases survival and corrects coagulopathy after eight-minute asphyxial cardiac arrest in the rat.

摘要: Introduction: No drug therapy has demonstrated improved survival following cardiac arrest (CA) of or noncardiac origin. In an effort to translate the cardiorescue properties Adenocaine (adenosine and lidocaine) magnesium sulfate (ALM) from surgery hemorrhagic shock resuscitation, we examined effect ALM on hemodynamic rescue coagulopathy asphyxial-induced CA in rat. Methods: Nonheparinized animals (400–500 g, n = 39) were randomly assigned 0.9% saline (n 12) 10) groups. After baseline data acquired, animal was surface cooled (33°C–34°C) ventilator line clamped for 8 min inducing CA; 0.5 mL solution injected intravenously followed by 60-s chest compressions (300/min), rats rewarmed. Return spontaneous circulation (ROSC), mean arterial pressure, heart rate, rectal temperature recorded 2 h. Additional randomized rotation thromboelastometry measurements 17). Results: Rats treated with had a significant benefit (100% vs. 67% controls achieved ROSC) generated higher pressure than did after 75 (81 72 mmHg at 120 min, P < 0.05). all rats, lysis index decreased during CA, implying hyperfibrinolysis. Control ROSC survivors displayed hypocoagulopathy (prolonged EXTEM/INTEM clotting time, clot formation prothrombin activated partial thromboplastin time), maximal firmness, lowered elasticity, amplitudes but no change index. These coagulation abnormalities corrected ROSC. Conclusions: Small bolus NaCl hemodynamics nonhemorrhagic, asphyxial prolonged times retraction compared controls.