Newcastle Disease Virus Interaction in Targeted Therapy against Proliferation and Invasion Pathways of Glioblastoma Multiforme

摘要: Glioblastoma multiforme (GBM), or grade IV glioma, is one of the most lethal forms human brain cancer. Current bioscience has begun to depict more clearly signalling pathways that are responsible for high-grade glioma initiation, migration, and invasion, opening door molecular-based targeted therapy. As such, application viruses such as Newcastle disease virus (NDV) a novel biological bullet specifically target aberrant in GBM brought new hope. The abnormal proliferation aggressive invasion behaviour reported be associated with Rac1 protein signalling. NDV interacts upon viral entry, syncytium induction, actin reorganization infected cell part replication process. Ultimately, intracellular stress leads undergo death. In this review, we describe characteristics malignant genetics drive its phenotype, focus on use oncolytic GBM-targeted therapy interaction inhibition subsequently,