Oncolytic viruses: do they have a role in anti-cancer therapy?

摘要: Oncolytic viruses are replication competent, tumor selective and lyse cancer cells. Their potential for anti-cancer therapy is based upon the concept that intratumoral will produce a potent anti-tumor effect possibly bystander or remote cell killing, whilst minimizing normal tissue toxicity. Viruses may be naturally oncolytic engineered activity, possess host of different mechanisms to provide selectivity. Clinical use live replicating associated with unique set safety issues. experience has so far provided evidence limited efficacy favourable toxicity profile. The interaction immune system complex. An anti-viral response limit by rapidly clearing virus. However, virally-induced lysis releases antigens in ‘dangerous’ context, suggests this can lead generation specific response. Combination chemotherapy radiotherapy represents promising avenue ongoing translation into clinical practice. Obstacles include highly effective non-specific clear virus following systemic delivery, immune-mediated clearance, barriers limiting spread. A number novel strategies now under investigation overcome these barriers. This review provides an overview role viruses, highlighting recent progress towards developing asks if they realistic therapeutic option at stage.