Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment
作者： Thai Minh Duy Le , Bo-Kyeong Jung , Yi Li , Huu Thuy Trang Duong , Thanh Loc Nguyen
DOI: 10.1039/C9BM00992B
关键词:
摘要: A dual pH- and temperature-responsive physically crosslinked injectable hydrogel system was developed for efficient long-term delivery of oncolytic adenoviruses (Ads). Three different types hydrogels with chemical compositions properties were prepared. These good biocompatibility can be injected at pH 9.0 room temperature rapidly form a gel under body or tumor microenvironment conditions. Ads encapsulated in released gradually without burst release. Moreover, these provided protective environment maintained their bioactivity long period time. Compared to naked Ads, protected by showed strong cytotoxicity cancer cells even after 11 days. The Ad-loaded also exhibited enhanced antitumor therapeutic effects human xenograft models. Due outstanding properties, might have potential treatment.
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Robin J Prestwich, Fiona Errington, Kevin J. Harrington, Hardev S. Pandha, Peter Selby, Alan Melcher, Oncolytic viruses: do they have a role in anti-cancer therapy? Clinical Medicine: Oncology. ,vol. 2, pp. 83- 96 ,(2008) , 10.4137/CMO.S416
Faris Farassati, An-Dao Yang, Patrick W. K. Lee, Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1 Nature Cell Biology. ,vol. 3, pp. 745- 750 ,(2001) , 10.1038/35087061
Ramon Alemany, Cristina Balagué, David T. Curiel, Replicative adenoviruses for cancer therapy Nature Biotechnology. ,vol. 18, pp. 723- 727 ,(2000) , 10.1038/77283
Hye Jin Sim, Thavasyappan Thambi, Doo Sung Lee, Heparin-based temperature-sensitive injectable hydrogels for protein delivery Journal of Materials Chemistry B. ,vol. 3, pp. 8892- 8901 ,(2015) , 10.1039/C5TB01399B
P Seth, L T Lay, T C Meeker, J M Wroblewski, F Turturro, Z Li, Adenoviral vectors efficiently target cell lines derived from selected lymphocytic malignancies, including anaplastic large cell lymphoma and Hodgkin's disease. Clinical Cancer Research. ,vol. 3, pp. 357- 364 ,(1997)
Tianyuan Ci, Liang Chen, Ting Li, Guangtao Chang, Lin Yu, Jiandong Ding, Effects of amphiphilic block copolymers on the equilibrium lactone fractions of camptothecin analogues at different pHs. Biomaterials Science. ,vol. 1, pp. 1235- 1243 ,(2013) , 10.1039/C3BM60152H
A. Hatefi, J. Cappello, H. Ghandehari, Adenoviral Gene Delivery to Solid Tumors by Recombinant Silk–Elastinlike Protein Polymers Pharmaceutical Research. ,vol. 24, pp. 773- 779 ,(2007) , 10.1007/S11095-006-9200-5
Hyo Jung Moon, Du Young Ko, Min Hee Park, Min Kyung Joo, Byeongmoon Jeong, Temperature-responsive compounds as in situ gelling biomedical materials Chemical Society Reviews. ,vol. 41, pp. 4860- 4883 ,(2012) , 10.1039/C2CS35078E
Carla Heise, David H. Kirn, Replication-selective adenoviruses as oncolytic agents Journal of Clinical Investigation. ,vol. 105, pp. 847- 851 ,(2000) , 10.1172/JCI9762
Kytai Truong Nguyen, Jennifer L. West, Photopolymerizable hydrogels for tissue engineering applications. Biomaterials. ,vol. 23, pp. 4307- 4314 ,(2002) , 10.1016/S0142-9612(02)00175-8