Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population.

摘要: Urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) are a class of PAH metabolites used as biomarkers for assessing human exposure to PAHs. The Centers Disease Control and Prevention's National Health Nutrition Examination Survey (NHANES) uses OH-PAHs establish reference range concentrations the US population, set benchmarks future epidemiologic biomonitoring studies. For years 2001 2002, 22 OH-PAH were measured in urine specimens from 2748 NHANES participants. Percentages samples with detectable levels ranged nearly 100% naphthalene, fluorene, phenanthrene, pyrene, less than 5% parent compounds higher molecular weight such chrysene, benzo[c]phenanthrene, benz[a]anthracene. geometric mean 1-hydroxypyrene (1-PYR)--the most commonly biomarker exposure--was 49.6 ng/L urine, or 46.4 ng/g creatinine. Children (ages 6-11) generally had did adolescents 12-19) adults 20 older). Model-adjusted, least-square means 1-PYR 87, 53 43 children, older), respectively. Log-transformed major significantly correlated each other. correlation coefficients between other ranging 0.17 0.63 support use useful surrogate representing exposure.