Induced Nitric Oxide Synthase as a Major Player in the Oncogenic Transformation of Inflamed Tissue
作者： Guang-Yu Yang , Sofia Taboada , Jie Liao
DOI: 10.1007/978-1-60327-530-9_8
关键词:
摘要: Nitric oxide (NO) is a free radical that involved in the inflammatory process and carcinogenesis. There are four nitric synthase enzymes NO production: induced (iNOS), endothelial (eNOS), neural (nNOS), mitochondrial NOS. iNOS an inducible key enzyme inflamed tissue. Recent literatures indicate as well eNOS can modulate cancer-related events including nitro-oxidative stress, apoptosis, cell cycle, angio-genesis, invasion, metastasis. This chapter focuses on linking NO/iNOS/eNOS to inflammation carcinogenesis from experimental evidence potential targets cancer prevention treatment.
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